{"product_id":"fox-04-dri","title":"FOX04-DRI 10mg","description":"\u003ch1\u003e\u003cspan\u003eFOXO4-DRI 10mg\u003c\/span\u003e\u003c\/h1\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eCellular Senescence Research | Senolytic Pathways | Healthy Ageing Research\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003cdiv\u003e\u003chr\u003e\u003c\/div\u003e\n\u003ch3\u003e\u003cstrong\u003e\u003cspan\u003eProduct Highlights\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003e10mg per vial\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e of FOXO4-DRI (subject to product specification)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eInvestigated for potential \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003esenolytic activity\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e in preclinical research\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eStudied for its interaction with \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003eFOXO4 and p53 signalling pathways\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eResearch interest in \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003ecellular senescence and ageing-related processes\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eInvestigated for its potential to selectively affect certain senescent cells\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eSupplied as a \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003elyophilized powder\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e, where specified by the manufacturer\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eResearch compound intended for laboratory investigation\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv\u003e\u003chr\u003e\u003c\/div\u003e\n\u003ch3\u003e\u003cstrong\u003e\u003cspan\u003eWhat is FOXO4-DRI?\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eFOXO4-DRI\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e is an experimental, cell-penetrating peptide designed to investigate the relationship between the transcription factor \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003eFOXO4\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e and the tumour-suppressor protein \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003ep53\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eIt has attracted scientific interest for its potential role in \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003ecellular senescence research\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e, particularly its ability to influence the survival of certain senescent cells.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eSenescent cells are cells that have permanently or persistently stopped dividing but remain metabolically active. Some can accumulate with age and contribute to inflammatory signalling through the \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003esenescence-associated secretory phenotype (SASP)\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eFOXO4-DRI has been studied as a potential \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003esenolytic compound\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e, meaning a substance investigated for its ability to promote the elimination of senescent cells.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003ePreclinical research has explored its potential relevance to \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003eageing biology, tissue function, cellular stress responses, and senescence-associated inflammation\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cspan\u003eResearch remains at an early stage, and its safety and effectiveness in humans have not been established.\u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv\u003e\u003chr\u003e\u003c\/div\u003e\n\u003ch3\u003e\u003cstrong\u003e\u003cspan\u003eHow It Works\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eCellular Senescence Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Investigated for its potential to influence the survival and elimination of certain senescent cells\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eFOXO4–p53 Interaction:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Designed to interfere with the interaction between FOXO4 and p53, proteins involved in cellular stress and survival signalling\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eSenolytic Pathways:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Studied for its ability to promote apoptosis (programmed cell death) in selected senescent cell populations under experimental conditions\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eHealthy Ageing Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Investigated in preclinical models exploring the biological consequences of senescent-cell accumulation\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eInflammatory Signalling:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Research interest in whether removing certain senescent cells may influence SASP-associated inflammatory processes\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eTissue Function Research:\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e Explored in laboratory and animal models examining tissue responses associated with cellular ageing\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv\u003e\u003chr\u003e\u003c\/div\u003e\n\u003ch3\u003e\u003cstrong\u003e\u003cspan\u003eWhat You'll Receive\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003e1x \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003e10mg vial\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e of FOXO4-DRI\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eLyophilized peptide powder\u003c\/span\u003e\u003c\/strong\u003e\u003cspan\u003e, subject to the supplied product specification\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eResearch-grade product, with quality specifications provided by the supplier\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eSecurely packaged for shipping\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cdiv\u003e\u003chr\u003e\u003c\/div\u003e\n\u003ch3\u003e\u003cstrong\u003e\u003cspan\u003eStorage Instructions\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eStore according to the \u003c\/span\u003e\u003cstrong\u003e\u003cspan\u003emanufacturer's validated storage specifications\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eProtect from direct light and moisture\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eKeep the vial securely sealed\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eAvoid unnecessary temperature fluctuations\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eFollow the batch-specific documentation for storage conditions and stability\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cem\u003e\u003cspan\u003eStorage requirements may vary by formulation. Refrigerated or frozen storage should only be specified where supported by the manufacturer's stability data.\u003c\/span\u003e\u003c\/em\u003e\u003c\/p\u003e\n\u003cdiv\u003e\u003chr\u003e\u003c\/div\u003e\n\u003ch3\u003e\u003cstrong\u003e\u003cspan\u003ePurity \u0026amp; Quality\u003c\/span\u003e\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cspan\u003eFOXO4-DRI is a specialised research peptide for laboratory investigation. Quality assessment may include:\u003c\/span\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003ePeptide identity verification\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003ePurity analysis using appropriate analytical methods\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eBatch consistency assessment\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp\u003e\u003cspan\u003eReview of applicable certificates of analysis (COAs)\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cspan\u003eProduct purity, manufacturing standards and quality-control claims should be supported by batch-specific testing documentation.\u003c\/span\u003e\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003e\u003cspan\u003eFor laboratory research purposes only. FOXO4-DRI is an experimental peptide and is not approved for human use or for the diagnosis, treatment, cure or prevention of disease. Its safety and efficacy in humans have not been established.\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e","brand":"ElementBio","offers":[{"title":"Default Title","offer_id":67831104176447,"sku":null,"price":290.0,"currency_code":"AUD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0953\/5003\/0655\/files\/339F2D23-4E1B-49D5-BB4E-D810F98C6E3A.png?v=1788398730","url":"https:\/\/elementbio.com.au\/products\/fox-04-dri","provider":"ElementBio","version":"1.0","type":"link"}